Nutrient Innovations, Inc. is a proud authorized US distributor for Bacillus Coagulans Unique IS-2. Recognized for its safety and extensively documented benefits, Unique IS-2 is a gram-positive, spore-forming probiotic known for its exceptional resilience and scientific validation.

Unique IS-2:
Clinically Proven,
Ultra-Stable Probiotic

Your go-to strain for superior digestive, immune and functional performance in all product formats—no microencapsulation needed.

A Unique Probiotic

Why Bacillus Coagulans Unique IS‑2 Stands Apart from Other Probiotics

This strain has received US FDA GRAS approval, distinguishing it as one of the few strains recognized by the U.S. Food and Drug Administration for its safety and efficacy. Additionally, it holds Health Canada-approved health claims and National Product Number (NPN) registration, underscoring its reliability and adherence to stringent regulatory standards. Bacillus coagulans Unique IS-2® is DNA tested for authenticity and proudly Kosher certified. Bacillus coagulans Unique IS-2® is not just a probiotic; it’s a holistic solution supported by an impressive 25 clinical studies, demonstrating its efficacy in enhancing various bodily functions. From promoting gut health, oral health, and immune health to aiding in weight management, diabetic support, and even benefiting our canine companions’ gut health, this strain has proven its versatility in fostering overall well-being.

Clinically Researched Health Benefits of Bacillus Coagulans Unique IS‑2®

Bacillus Coagulans Unique IS-2:
For Gut Balance

Clinically proven strain to help maintain digestive health.

Digestive Health Reinvented

Daily Defense with Bacillus Coagulans Unique IS-2

A safe and effective strain proven for its efficacy in boosting immunity in children and adults.

Immune Health Fortification

Bacillus Coagulans Unique IS-2:
Probiotics for Fitness

Unique IS-2 with whey protein for enhanced protein absorption.

Empowering Sports Nutrition & Fitness

Bacillus coagulans Unique IS-2® Food Applications

Bacillus coagulans Unique IS‑2® integrates seamlessly into a wide variety of food and supplement applications thanks to its exceptional resilience to heat, pH, and moisture. Whether incorporated into high-temperature baking processes, cold beverages, dairy products, or functional snacks, IS‑2 retains stability without requiring refrigeration or microencapsulation. Its spore-forming nature ensures excellent survivability through manufacturing, storage, and digestion—making it ideal for innovative formulations across health categories.

Baked Goods

Easily incorporated into muffins, cookies, granola bars, and cereals—retains viability through high-temperature baking.

Dairy & Non-Dairy Fermented Products

Compatible with yogurt, cheese, kefir, and plant-based alternatives—supports both live cultures and shelf-stable options.

Functional Beverages

Survives acidic, cold, or hot beverages including juices, smoothies, kombucha, coffee, and tea—without altering taste, aroma, or appearance.

Savory Applications

Compatible with yogurt, cheese, kefir, and plant-based alternatives—supports both live cultures and shelf-stable options.

Bacillus coagulans Unique IS-2® in Nutraceuticals

Bacillus coagulans Unique IS‑2® is a formulation-friendly probiotic ideal for a wide range of nutraceutical applications. Its naturally encapsulated spore structure allows it to survive manufacturing processes, shelf storage, and gastrointestinal transit without the need for refrigeration or protective coatings. This makes it highly compatible with diverse supplement delivery systems including capsules, tablets, powders, gummies, and liquid suspensions. Whether used as a standalone probiotic or combined with complementary ingredients like digestive enzymes, botanicals, or prebiotics, Unique IS‑2 offers reliable stability, clean-label appeal, and science-backed efficacy across consumer health categories.

Capsules & Tablets

Ideal for standalone probiotics or synergistic blends—maintains viability throughout GI transit and shelf life.

Powders & Stick Packs

Perfect for sachets, single-serve powders, and blends with prebiotics or digestive enzymes—easy to mix and consumer-friendly.

Softgels & Gummies

Stable without refrigeration, enabling inclusion in chewables, softgels, and gummies without sensory or stability compromises.

Oral Drops & Suspensions

Well-suited for liquid delivery in pediatric, geriatric, or pet supplements—retains potency in aqueous environments.

Ingredients Synergizing with Bacillus coagulans Unique IS-2®

Probiotic Powerhouses

Combine with high-quality prebiotics such as inulin or chicory root extract for enhanced probiotic potency.

Nutrient Boosters

Pair with vitamin D3 for amplified immune health support, creating a robust foundation for overall wellness.

Omega-3 Fatty Acids

Formulate with omega-3-rich ingredients like fish oil to promote heart health in a comprehensive manner.

Herbal Allies

Blend with herbal extracts like chamomile or peppermint for a holistic approach to digestive and gut well-being.

FAQs

What potencies are readily available for the spore-forming probiotic Bacillus coagulans Unique IS-2?

Our most common and readily available stock spec contains 15 billion CFU per gram.  Other popular potencies include 30 billion, and 100 billion CFU/g. Higher concentrations up to 200 billion CFU/g are available with 8–10 week lead time for this ultra-stable probiotic. 

What are the standard pack sizes and minimum order quantity (MOQ) for bulk ingredient Bacillus coagulans Unique IS-2?

Available in 5 kg, and 25 kg food-grade aluminum foil bags. MOQ is 5 kg regular production orders of this heat-stable probiotic. Small sample sizes are available as well.  

Do you offer custom premixes or blends with Bacillus coagulans Unique IS-2?

Yes. We routinely supply ready-to-use premixes with prebiotics (inulin, chicory root extract, FOS), and other strains to simplify your manufacturing process for this formulation-friendly probiotic.

Under normal storage (≤25 °C, low humidity), ≤0.5 log loss over 36 months. Typical overage needed is only 10–20 %, thanks to its naturally encapsulated spore structure. 

Is refrigeration required for the no refrigeration required Bacillus coagulans Unique IS-2 during storage or shipping?

No. This shelf-stable probiotic is fully moisture-stable and ultra-stable, requiring no refrigeration at any stage—warehouse, transport, or finished product—while maintaining viability through GI transit. 

Can the heat-stable Bacillus coagulans Unique IS-2 survive high-temperature processing such as baking, extrusion, or HPP?

Yes. Real-time and accelerated data show excellent survival in baking (up to 180–200 °C for muffins, cookies, granola bars, cereals), extrusion, retort, and high-pressure processing without microencapsulation.

Is Bacillus coagulans Unique IS-2 suitable for low-pH applications like functional beverages, gummies, or fruit-based products?

Absolutely. This pH-stable probiotic remains viable down to pH 2.5–3.0 with minimal loss over 18–24 months in acidic environments like juices, smoothies, kombucha, coffee, tea, or gummies, without altering taste, aroma, or appearance. 

What documentation is provided with each batch of DNA tested Bacillus coagulans Unique IS-2?

Certificate of Analysis (CFU count, pathogens, heavy metals), Allergen Statement, GMO status, Kosher certified documentation, Halal certificates, BSE/TSE-free declaration, and stability summary for this clean-label probiotic. Additional GMP documents available upon request. 

Do you offer Non-GMO Project Verified or organic-compliant versions of Bacillus coagulans Unique IS-2?

Standard production is non-GMO; Non-GMO Project Verified documentation is available. Organic-compliant fermentation can be arranged with 12–16 week lead time for this Kosher certified bulk ingredient. 

What is the typical lead time and technical support availability for the ultra-stable Bacillus coagulans Unique IS-2?

Stock potencies ship in 3–7 business days or within 3-4 weeks if we are between incoming shipments. Custom blends or potencies: 8–12 weeks. Free formulation and stability support from our PhD team is included with every order, ideal for applications in dairy, non-dairy fermented products like yogurt, cheese, kefir, plant-based alternatives, savory items, capsules, tablets, powders, stick packs, softgels, and oral drops. 

 

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